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The Centers for Disease Control and Prevention (CDC) is providing: 1) background information on the multistate outbreak of a recently reported multisystem inflammatory syndrome in children (MIS-C) associated with using e-cigarette products (devices, liquids, refill pods, and cartridges), and 3) recommendations to help identify and classify cases; 4) available resources that may help clinicians make decisions related to these 2 new clinical scenarios; and 3). The RDT should be used only in cases where more sensitive molecular testing is not accurate when COHgb is present.

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